Postdoctoral Researcher - Next-Generation CAR Immune Cell Therapies Against Malignant Brain Tumors (ERC-funded), 100 %

The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer! ###

Your responsibilities

Specific project goals:

• Generate CAR immune cell communities, comprising mixtures of engineered T cells, NK cells, monocytes, and additional cell types, using sophisticated in vitro and in vivo engineering platforms.
• Identify co-factors that boost CAR immune cell function using cutting-edge screening platforms.
• Investigate anti-tumor activity and immune-cancer-cell environmental crosstalk in vitro and in vivo using sophisticated disease models (organoids, slice cultures, patient-derived samples, mouse models) and modern technologies including flow cytometry, multiplexed imaging, spatial transcriptomics/proteomics and single-cell profiling.
• Analyze patient samples from an accompanying clinical trial evaluating CAR immune cell communities.

Your profile

• Intellectual curiosity, creativity and a proactive approach to problem-solving
• Motivation to contribute to a project with direct patient impact
• PhD in immunology, computational immunology, cell/molecular/cancer biology, bioengineering, biomedical sciences, or a related field
• Experience with immune cell engineering, cellular immunotherapy, and/or advanced in vitro/in vivo disease models is highly desirable
• Familiarity with single-cell and/or spatial technologies is a plus
• Strong publication record demonstrating scientific productivity
• Excellent communication skills and the ability to thrive in an interdisciplinary team

Tobias Weiss

Prof. Dr. med. Dr. sc. nat.

[email protected]